Descriere: Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
Autori: Michael Fossel (Author) | Editura: OXFORD UNIV PR | Anul aparitiei: 2004 | ISBN: 9780195140354 | Numar de pagini: 504 | Categorie: Family
Tovah P. Klein Phd (Author)
Raising Resilience: How to Help Our Children Thrive in Times of Uncertainty
6,USA Today BestsellerForeword by Amy SchumerChild development expert and author of How Toddlers Thrive, Dr. Tovah Klein gives parents the confidence they need to help children and teens build resilience and flourish in an unpredictable world.Whether it's national or global events affecting our sense of safety or stressors in our day-to-day lives, we are constantly confronted with situations that threaten the wellbeing of our children. Thankfully, there is good news that has not yet been reflected in the headlines: we can mitigate the effect of such rampant uncertainty by guiding our children to manage adversity and become more resilient. The key is parental involvement.Raising Resilience is a lifeline for every family contending with life's many stresses and traumas--from the most commonplace to the most devastating--including peer conflicts, divorce, family tensions, death, moving, academic struggles, and larger personal and national events. Through her years of experience and ongoing research, developmental psychologist Dr. Tovah Klein offers parents and caregivers five specific resources that children can develop, enabling them to face adversity, adjust, and thrive where they ...
William Stixrud (Author)
The Seven Principles for Raising a Self-Driven Child: A Workbook
5,From the authors of What Do You Say? and The Self-Driven Child, a workbook of vital practices and step-by-step resources for parents striving to raise self-motivated, secure, and joyfully driven children A guide to move from understanding the science and value behind nonanxious parenting to developing and sharpening the essential skills parents need to be a trusted resource for growing kids. Authors William Stixrud and Ned Johnson have watched firsthand as the crisis around education and the mental health crisis in childhood have converged in the postpandemic years. Their book The Self-Driven Child was ahead of the curve in addressing the way these forces converge in adolescents at pivotal moments as children develop their sense of autonomy, ambition, self-discipline, and learning style. As the authors have continued to lecture on the book's subject, parents have again and again homed in on the value of the model dialogues and practice prompts. Using material from their current work with parents and children, and pulling essential principles from the science in The Self-Driven Child, this workbook guides parents to develop the practice of being a nonanxious presence in children's ...
Michael Thompson
The push for students to excel at school and get into the best colleges has never been more intense. In this invaluable new book, the bestselling co-author of Raising Cain addresses America's performance-driven obsession with the accomplishments of its kids-and provides a deeply humane response."How was school?" These three words contain a world of desire on the part of parents to know what their children are learning and experiencing in school each day. Children may not divulge much, but psychologist Michael Thompson suggests that the answers are there if we know how to read the clues and-equally important-if we remember our own school days.School, Thompson reminds us, occupies more waking hours than kids spend at home; and school is full not just of studies but of human emotion-excitement, fear, envy, love, anger, sexuality, boredom, competitiveness. Through richly detailed interviews, case histories, and student e-mail journals, including those of his own children, Thompson illuminates the deeper psychological journey that school demands, a journey that all children must take in order to grow and develop, whether they are academic aces or borderline dropouts. Most of us remember ...